Frankel will face a maximum of 14 rivals in the Qipco 2000 Guineas at Newmarket on Saturday.
Henry Cecil's unbeaten colt is set to go off the shortest priced favourite for the Classic in over 30 years.
Jessica Harrington's Pathfork is another unbeaten youngster heading to Headquarters and is expected, by the bookmakers at least, to give the market leader most to do.
The leading Aidan O'Brien representative this year is Roderic O'Connor, second to Frankel in the Dewhurst and a Group One winner in France as a juvenile. O'Brien has also left in Master Of Hounds and Alexander Pope.
Native Khan, the winner of the Craven Stakes, and William Haggas' unbeaten Fury are others who could give the favourite something to think about.
Godolphin have left in Saeed bin Suroor's Saamidd and Casamento, trained by Mahmood Al Zarooni. Dubai Prince was intended to be Al Zarooni's Guineas horse but he misses the race through injury.
"The main Classic horse I have is Casamento and a decision will be made soon on whether he goes to the 2000 Guineas on Saturday or waits for the Dante," Al Zarooni told www.godolphin.com.
"Casamento is a good horse who is doing well. He wants further than a mile and although the Guineas is a great Classic it is always a good trial for the Derby."
Broox, Dubawi Gold, Happy Today, Loving Spirit, Rerouted and Slim Shadey complete the possibles.
Dream Ahead was among the four withdrawals, with trainer David Simcock admitting defeat that he is not going to get his favoured ground.
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